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Friday, July 31, 2020 | History

2 edition of Epoxidation of aldrin by rainbow trout liver microsomes found in the catalog.

Epoxidation of aldrin by rainbow trout liver microsomes

Timothy Ming-wai Chan

Epoxidation of aldrin by rainbow trout liver microsomes

by Timothy Ming-wai Chan

  • 352 Want to read
  • 17 Currently reading

Published .
Written in English

    Subjects:
  • Pesticides -- Toxicology.,
  • Fishes -- Physiology.,
  • Drugs -- Metabolism.

  • Edition Notes

    Statementby Timothy Ming-wai Chan.
    The Physical Object
    Pagination[9], 51 leaves, bound :
    Number of Pages51
    ID Numbers
    Open LibraryOL14254145M

    Epoxidation of aldrin The most important transformation of aldrin in the soil is its conversion by epoxidation to dieldrin (Fig. 2, section ). Epoxidation, essentially biological in nature (Lichtenstein & Schulz, ), occurs in all aerobic and biologically active soils, and about 50 - 70% of the residues remaining in a soil at the end. Chironomus tentans Rainbow trout, Salino gairdneri 30 days 24 hrs days Rainbow trout, Salmo gairdneri LC50 LC50 I.C50 Lethal muscle tissue bioconcentration 1AO days Altered concentrations of 11 amino acids 6, bitten & Goodnight, Buikley. et al. 2 Jensen & Gaufin. ', Jensen & Gaufin. Karnak 6.

    Metabolism of aflatoxin B1 in Turkey liver microsomes: The relative roles of cytochromes P 1A5 and 3A Toxicology and Applied Pharmacology , (3), DOI: / Leposava Antonovic, Marilyn Martinez. Rainbow Trout Human Liver Human Liver Microsome Aspergillus Parasiticus Microsomal Epoxide Hydrolase These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

    Buzzi, M., Henderson, R.J. and Sargent, J.R. The desaturation and elongation of linolenic acid and eicosapentaenoic acid by hepatocytes and liver microsomes from rainbow trout (Oncorhynchus mykiss) fed diets containing fish oil or olive oil. Biochim. Biophys. Acta Google Scholar. Audio Books & Poetry Community Audio Computers, Technology and Science Music, Arts & Culture News & Public Affairs Non-English Audio Spirituality & Religion. Librivox Free Audiobook. Real & Raw Podcast Podcasts – The Well Examined Life Jefferson Techno Podcast Ranked!


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Epoxidation of aldrin by rainbow trout liver microsomes by Timothy Ming-wai Chan Download PDF EPUB FB2

At 37° C and pHrainbow trout liver microsomes, incubated with millimicromoles of either aldrin or heptachlor in the presence of reduced triphosphopyridine nucleotide (NADPH) and oxygen, produced only milli-micromole of the corresponding expoxides, dieldrin and heptachlor : Timothy Ming-wai Chan.

Abstract. Graduation date: Assay conditions and analytical methods established for the\ud study of epoxidation of the insecticides aldrin and heptachlor, by\ud rat liver microsomes have been employed to study the same reaction\ud catalyzed by trout liver microsomes.

TABLE 4-EPOXIDATION* OF ALDRIN BY VARIOUS COMBINATIONS OF TROUT AND RAT LIVER MICROSOME FRACTIONS Activity Activity Rat fractiont No addition +Rat P-I Trout fractionf No addition +Rat P-I P-I - P-I tr P-II tr$ P-II tr P-III - P-III tr S-1 S-1 tr S-II tr S-II tr S-III tr S-III tr Cited by: The average cytochrome P content of gilthead seabeam liver microsomes was found to be ± (n = 4) nmol/mg protein, which was about 50%, 24% and 13% of that measured in trout.

1. Hepatic microsomal mixed-function oxidase of the frog, Xenopus laevis appears to be similar to that of fish and mammals.

However, the levels of protein in liver microsomes, and specific contents and activity of cytochrome P, cytochrome c reductase, aldrin and chlordane epoxidase, and naphthalene and chlordene hydroxylase of frog liver are about 30–40% of these of Cited by: 9. Aflatoxin B1 and aflatoxicol metabolism in rainbow trout (Salmo gairdneri) and the effects of dietary cyclopropene.

Loveland PM, Nixon JE, Pawlowski NE, Eisele TA, Libbey LM, Sinnhuber RO. Aflatoxin M1 was identified as a minor metabolite formed by the in vitro incubation of aflatoxin B1 with the postmitochondrial fraction or microsomes from.

The liver slices and homogenates of fresh water fish can oxidatively desulfurate parathion in the case of the brook trout, the brown trout, the mud puppy (L.

gibbosa, L melas, P. americanus and M. scorpius) and can convert trimethylamine to its N-oxide as seen with several other fresh water fish (Potter & O'Brien, ; Murphy, ). Purchase Microsomes, Drug Oxidations and Chemical Carcinogenesis V2 - 1st Edition.

Print Book & E-Book. ISBN  Benzo[a]pyrene hydroxylase activity of trout liver microsomes was similar to that of rat and quail microsomes, whereas hydroxylation of substrates which in rat liver are preferentially me tabolized by phenobarbital-Inducible forms of cytochrome P was much lower in trout mi crosomes.

Academic Press, Inc. INTRODUCTION Several. Lech JJ. Glucuronide formation in rainbow trout--effect of salicylamide on the acute toxicity, conjugation and excretion of 3-trifluoromethylnitrophenol. Biochem Pharmacol. Sep 1; 23 (17)– Ludke JL, Gibson JR, Lusk CI. Mixed function oxidase activity in freshwater fishes: aldrin epoxidation and parathion activation.

Until then it was generally assumed that apart from the already well known epoxidation reactions of chemicals such as aldrin, 1 these compounds were rather inert biologically. Keywords Liver Microsome Mosquito Larva Epoxide Ring Epoxidation Reaction Heptachlor Epoxide.

Abstract. Aflatoxin B 1 (AFB 1) is the most toxic and carcinogenic member of a family of difuranocoumarins produced as secondary metabolites by strains of Aspergillus flavus and related fungi re to aflatoxin is a public health hazard in technologically developing areas of the world, where AFB 1-producing fungi are distributed widely and where food production and storage conditions are.

The purpose of the present study was to elucidate in vitro effects of Hg(2+), Zn(2+), Ni(2+) and Cd(2+) on cytochrome PA1 (CYP1A1) dependent EROD activities in leaping mullet liver microsomes. Metabolism of 7-ethoxycoumarin in human liver microsomes was studied as early as in [].

Its primary metabolic pathways have been reported as O-deethylation and subsequential glucuronidation and sulfation in in vitro human [ 11 - 13 ], monkey [ 12, 14 ], dog [ 15 ], rat [ 12, 16 - 23 ], pig [ 12, 15, 24 ], mouse [ 12, 18 ], rabbit.

12 Liver from trout dosed with 0. 56 mg/kg R F. 69 13 Liver from trout dosed with 1. 27 mg/kg R R. 70 14 Normal trout liver. 71 15 Normal trout kidney. 71 16 Kidney from trout dosed with 0. 4 mg/kg B. 72 17 Kidney from trout dosed with 1. 27 mg /kg R R. 72 18 Kidney from trout dosed with 0.

Aldrin Epoxidation in Flathead Mullet (Mugil cephalus): Possible Involvement of CYP1A and CYP3A. In liver microsomes of rainbow trout, inhibition of cytochrome P (CYP) caused a respective 7.

Andersson T, Pesonen M, Johansson C. Differential induction of cytochrome Pdependent monooxygenase, epoxide hydrolase, glutathione transferase and UDP glucuronosyl transferase activities in the liver of the rainbow trout by beta-naphthoflavone or Clophen A Biochem Pharmacol.

Sep 15; 34 (18)– Insects. Localization and Properties of an Enzyme System Affecting Aldrin Epoxidation in Larvae of the Southern Armyworm (Prodenia eridania). Biochem. Use of Monkey Liver Microsomes in Production of Aflatoxin Q1. Agric.

Food Strawberry Disease in Rainbow Trout, Salmo gairdneri Richardson. Fish Dis. 8: Renzi, B. Rainbow trout (Salmo gairdneri)and coho salmon (Oncorhyn-chus kisutch) were exposed to aflatoxin B1(AFB1) either by passive embryo uptake or by dietary treatment after hatching and feeding onset.

Trout exposed as embryos to an aqueous solution of p.p.m. AFB1 for 15 min showed a 62% tumor incidence 12 months later, whereas coho salmon exposed to a similar solution for 30 min showed only.

The fiddler crab Uca pugnax was examined for its ability to metabolize foreign hydrocarbons. The microsomal mixed function oxidase system was identified in U. pugnax tissues using Aldrin epoxidation rates as the assay. Rates were slow: 96 pM Dieldrin per mg microsomal protein per hour in the hepatopancreas, pM mg-1 h-1 in the gill, and pM mg-1 h-1 in claw-muscle microsomes.

Ludke JL, Gibson JR, Lusk CI. Mixed function oxidase activity in freshwater fishes: aldrin epoxidation and parathion activation. Toxicol Appl Pharmacol. Jan; 21 (1)– Melancon MJ, Williams DE, Buhler DR, Lech JJ.

Metabolism of 2-methylnaphthalene by rat and rainbow trout hepatic microsomes and purified cytochromes PAldrin, dieldrin Mosquito fish (28) extreme sensitivity of rainbow trout to aflatoxin-in-duced carcinogenesis. Also, differences in the metabo-lism of 2-methylnaphthalene (2-MeN) have been dem- to BaP-7,8-diol by liver microsomes of the sole and flounder than byrat microsomes.The marginal ability of fish to perform oxidative metabolic changes on foreign compounds was confirmed in studies by Chan, Gillett & Terrier e (19), using the conversion of aldrin to dieldrin as the test reaction.

Liver TERRIERE microsomes of rainbow trout were less than one tenth as active in the epoxidation reaction as those prepared from rats.